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在重症监护室中,聚胺B的毒性及其前体的风险:一项回顾性队列研究

Hüseyin Özkarakaş¹, Yeliz Özdemir², Selma Tosun²

¹Intensive Care Unit, University of Health Sciences Izmir Bozyaka Training and Research Hospital, Izmir, TUR.

|October 2, 2023

概括

在35%的重症患者中,波利米辛B导致损伤. 高龄,高BMI和使用时间较长是毒性的主要危险因素.

科学领域:

临界护理医学临界护理医学
腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病

背景情况:

聚氨酸抗生素对于治疗多药耐药性细菌阴性感染至关重要.
毒性是多素使用的显著限制,需要进一步调查.
了解polymyxin B对脏的影响对于优化患者护理至关重要.

研究的目的:

评估重症患者中与聚米辛B相关的毒性发生率.
为了确定有助于多素B诱导的损伤的独立风险因素.
为了告知临床实践关于安全的polymyxin B的管理.

主要方法:

对成年ICU患者进行了回顾性队列研究,这些患者接受了72小时以上的polymyxin B治疗.
排除先前存在功能衰竭或急性损伤 (AKI) 的患者.
在AKI治疗后与没有AKI治疗后组之间的患者特征的比较.

主要成果:

35%的患者 (21/60) 在polymyxin B治疗后出现了毒性 (NT).
观察到的统计学上显著的差异是晚年,低GFR,高肌素,BMI,并发症和使用时间.
多变量分析确定使用时间,BMI和晚年是AKI的独立风险因素.

结论:

在没有先前脏问题的重症患者中,多素B与35%的损伤率有关.
高龄,BMI升高和长期暴露于多素B是毒性的独立预测因素.
建议对接受多素B的患者进行密切的功能监测和早期干预,特别是那些具有已确定的风险因素的患者.

关键词:

急性脏损伤急性脏损伤是什么耐卡巴尼姆的克拉姆阴性感染.在重症监护病房.毒性毒性毒性聚米辛-b-b的使用方法这是一种血症.

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