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洞察Nrf2:从2000年到2022年的文献计量和视觉分析

Yawei Ma¹, Zhongqing Wang², Yuedong Hu¹

¹Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China.

Frontiers in genetics

|October 2, 2023

概括

这份图书统计分析显示,全球研究核素红色素2相关因子2 (Nrf2) 和其在氧化应激,癌症和神经系统疾病中的作用显著增加. 未来的趋势集中在新的分子机制和有针对性的治疗干预.

科学领域:

生物化学和分子生物学
药理学和毒理学药理学和毒理学
遗传学和基因组学在

背景情况:

核因子红色素2相关因子2 (Nrf2) 是细胞抗氧化防御的主调节者.
Nrf2在减轻氧化损伤和炎症方面的作用使其成为关键的治疗点.
对Nrf2研究的文献分析很少,需要一个全面的概述.

研究的目的:

分析2000年至2022年Nrf2的全球研究格局.
确定Nrf2研究中的关键趋势,有影响力的出版物和新兴研究热点.
为未来针对 Nrf2.2 的治疗策略提供见解.

主要方法:

从科学网络核心图书馆 (2000-2022) 中对22,040篇出版物的图书法分析.
使用微软Excel,CiteSpace,Bibliometrix和VOSviewer进行数据收集和可视化.
关键词聚类来分类研究主题.

主要成果:

全球Nrf2研究已经大幅增长,中国在出版物方面领先,美国在引用方面领先.
关键的研究领域包括氧化应激,癌症,糖脂代谢障碍,炎症和神经疾病.
自由激进生物学和医学是最多产的期刊,玛萨尤基·亚马莫托和伊托赫·K.是被引用的作者.

结论:

中国和美国是Nrf2研究的领导者,最近的重点是实验,临床和治疗方面.
未来的研究可能会探索新的分子机制 (NF-κB,Ho1,Keap1) 和向的Nrf2调节器.
了解Nrf2与癌症,代谢障碍和神经疾病等疾病之间的相互作用对于治疗发展至关重要.

关键词:

Nrf2 没有任何问题.在VOSviewer中使用VOSviewer.文献计量分析的分析引用空间就是一个引用空间.视觉化的可视化

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