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Updated: Jul 15, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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通过对癌症治疗的药物重新定位来准MDM2-p53轴:一种多学科的方法

Naeem Abdul Ghafoor1, Aysegul Yildiz1,2

  • 1Department of Molecular Biology and Genetics, Graduate School of Natural and Applied Sciences, Mugla Sitki Kocman University, 48000 Mugla, Turkey.

ACS omega
|October 2, 2023
PubMed
概括

研究人员通过重新利用抗组胺药物确定了 cetirizine (CZ) 作为一种潜在的癌症治疗方法. 这种药物抑制了小鼠双分钟2 (MDM2),激活了瘤抑制器p53通路,并对癌细胞表现出抗增殖作用.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics06:00

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