肢体骨折儿童血清维生素C水平较低:一个病例对照研究
Yangkun Ding1, Chunhua Wang1, Jiazhi Yu1
1Department of Pediatric Orthopedics, Jinan Children's Hospital, Jinan, China.
Frontiers in pediatrics
|October 2, 2023
概括
患有四肢骨折的儿童显示血清维生素C水平明显降低. 这种缺乏症在4岁及以上的儿童中更为明显,突出的是维生素C.
科学领域:
- 儿科整形外科 儿科整形外科
- 营养生物化学 营养生物化学
背景情况:
- 维生素C在儿科骨折中的作用尚未得到充分研究.
- 维生素C以其在预防老年人骨质疏松性骨折中的作用而闻名.
研究的目的:
- 为了研究被诊断为四肢骨折的儿童的血清维生素C水平.
- 为了比较儿科骨折患者和对照组之间的维生素C水平.
主要方法:
- 一项病例控制研究,涉及325名肢体骨折的儿童和316名对照.
- 收集的数据包括基本的人口统计和禁食血清维生素C水平.
- 血清维生素C的定量使用超高性能液体染色学-并联质谱法.
主要成果:
- 与对照组 (8.38μg/ml) 相比,四肢骨折的儿童的血清维生素C水平 (4.48μg/ml) 显著降低 (p < 0.0001).
- 在4岁以上的骨折患者中,血清维生素C水平显著下降.
- 在骨折组中观察到年龄和血清维生素C水平之间存在负相关性.
结论:
- 儿科四肢骨折与血清维生素C水平降低有关.
- 这些发现表明,维生素C状况与儿童,特别是老年儿童骨折风险之间存在潜在联系.
关键词:
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