严重喘中的支气管切除与埃索诺菲尔性气道炎症和激活有关
Laurits Frøssing1,2, Anna Von Bülow1, Celeste Porsbjerg1,2
1Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
支气管切除症在严重的喘中很常见,并且与酸性气道炎症有关. 这项研究发现,在患有支气管切除症的患者中,乙素脱粒和特定基因表达增加.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 呼吸道疾病 呼吸道疾病
背景情况:
- 支气管切除症是严重喘中经常出现的并发症.
- 致病机制尚未完全理解,可能与其他原因有所不同.
- 与喘相关的支气管炎症中eosinophilic呼吸道炎症的作用尚不清楚.
研究的目的:
- 为了确定严重喘患者中支气管切除症的患病率.
- 为了研究支气管切除症和埃索诺菲尔呼吸道炎症/激活之间的关联.
主要方法:
- 包括患有严重喘 (高剂量ICS/OCS) 的患者.
- 使用高分辨率计算机断层扫描 (HRCT) 进行诊断.
- 分析诱导的唾液细胞计数,乙素脱粒和T2通路mRNA.
主要成果:
- 在31%的严重喘患者中发现了支气管切除症.
- 患有支气管切除症的患者表现出明显更高的唾液中异氨基细胞数量 (5.3对0.8,P=.001).
- 在支气管切除症患者中观察到较高的乙素脱粒 (13%与2%相比,P=.05) 和Charcot-Leyden晶体甲状腺素mRNA表达.
结论:
- 严重喘中的支气管切除与异性气道炎症有关.
- 乙氨基酸脱粒和Charcot-Leyden晶体加勒 mRNA表达与这个人群中的支气管切除症有关.
相关概念视频
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management
433
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
433
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
COPD: Management Using Bronchodilators and Corticosteroids
236
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
236


