喘相关的细菌感染:它们是保护性的还是有害的?
Thais Fernanda de Campos Fraga-Silva1, Mèdéton Mahoussi Michaël Boko2, Núbia Sabrina Martins2
1Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
喘涉及不同的炎症类型,包括T助手17 (TH17) 细胞反应. 激活TH17中性粒细胞通路的细菌感染有助于难以治疗的喘和皮质类固醇耐药性.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 微生物学 微生物学
背景情况:
- 喘在颗粒细胞炎症 (eosinophilic,nonosinophilic,混合) 中表现出异质性.
- 喘中的免疫反应可以是T助手2 (TH2) - 容易或T助手17 (TH17) - 容易,受到肺细胞原始化的影响.
- 细菌感染 (例如,血球菌,摩拉塞拉菌,菌株菌) 触发IL-17分泌,将中性粒细胞招募到呼吸道.
研究的目的:
- 审查TH17-中性粒细胞轴在喘发病过程中的作用.
- 探索细菌感染如何加剧喘并导致皮质类固醇耐药性.
- 要突出呼吸道上皮细胞的参与,S100A9,和高流动性组框1在严重的喘.
主要方法:
- 临床研究和实验性喘模型的审查.
- 对调节TH17-中性粒细胞轴的通路的分析.
- 对现有发现和未来研究方向的批判性评估.
主要成果:
- 由细菌感染激活的IL-17中性粒细胞轴驱动的中性粒细胞透与一种抗皮质固醇喘表型有关.
- 空气道上皮细胞,S100A9和高流动性组框1都涉及到这个轴.
- 了解这些途径对于开发有针对性的疗法至关重要.
结论:
- 由于细菌感染而加剧的TH17中性粒细胞轴在严重的,难以治疗的喘中起着重要作用.
- 针对这一轴和相关分子可能为严重喘提供新的治疗策略.
- 需要进一步的研究来开发有效的免疫疗法来控制严重的喘.
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