人类免疫缺陷病毒是发展非工会的风险因素吗? - - 一项病例控制研究
Simon Matthew Graham1,2,3, Sithombo Maqungo3,4,5, Maritz Laubscher3,4
1Oxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
概括
人类免疫缺陷病毒 (HIV) 感染不会增加骨折的风险. 这一发现表明,艾滋病毒感染者可以接受与艾滋病毒阴性患者相同的骨折治疗.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 骨折非结合在骨科手术中构成了重大挑战.
- 以前的研究表明,人类免疫缺陷病毒 (HIV) 感染与非工会风险增加之间存在潜在联系.
- 了解受损骨折愈合的风险因素对于患者的治疗结果至关重要.
研究的目的:
- 调查艾滋病毒状态与股骨或骨骨折中非结合的发展之间的关联.
- 确定影响南非队列中骨折愈合的常见风险因素.
主要方法:
- 在2017年12月至2019年4月期间进行了前性匹配病例控制研究.
- 已建立非工会 (案例) 的成年人与取得骨折工会的对照人进行了匹配.
- 参与者进行了艾滋病毒检测,多变量逻辑回归分析了非工会的风险因素.
主要成果:
- 艾滋病毒状况与骨和大腿骨骨折的非结合发展没有显著关联 (单变OR 0.40,P=0.151;多变OR 0.86,P=0.831).
- 在这个队列中,没有其他混因素显示出对非工会风险的统计显著影响.
结论:
- 这项研究表明,艾滋病毒感染似乎不会增加骨折非结合风险.
- 患有骨折的艾滋病毒阳性个体可以与艾滋病毒阴性患者相似地管理.
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