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Updated: Jul 15, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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通过电场扰乱二极体β-粉样蛋白.

Pablo Andrés Vargas-Rosales1, Alessio D'Addio1, Yang Zhang1

  • 1Department of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland.

ACS physical chemistry Au
|October 2, 2023
PubMed
概括

在研究粉样β模体时,研究人员发现振荡的电场可以破坏这些有毒的阿尔茨海默病寡合体. 通过分子动力学观察到的这种干扰表明了潜在的新治疗途径.

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Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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