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意大利的花生过敏:意大利独特的视角
Riccardo Asero1, Eleonora Nucera2, Angela Rizzi2
1Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
意大利的花生过敏症的特点是特定的蛋白质敏感化,与格鲁-撒克逊国家不同. 脂质转移蛋白 (LTP) 过敏在意大利中部/南部很常见,而种子储存蛋白 (SSP) 在北部占主导地位.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
- 流行病学 流行病学
背景情况:
- 在意大利,花生过敏的特征是有限的.
- 了解花生过敏的区域差异至关重要.
研究的目的:
- 定义意大利花生过敏的临床特征.
- 为了确定涉及意大利过敏的特定花生蛋白质.
主要方法:
- 在意大利22个中心进行了6个月的前性调查.
- 通过体内/体外诊断证实了临床病史.
- 测量IgE水平对特定的花生过敏原 (Ara h 1-3, 6, 8-9) 和蛋白质.
主要成果:
- 纳入了395名患者,35%的局部反应,38.2%的全身反应,26.6%的过敏反应.
- 主导性对Ara h 9 (77%) 的敏感性,其次是PR-10 (35%) 和SSP (26%).
- 与严重程度相关的LTP/SSP敏感化;与较轻的反应相关的profilin/PR-10. 观察到SSP/LTP流行率的区域差异.
结论:
- 意大利的花生过敏很少见,具有不同的区域敏感性概况 (中南部的LTP,北部的SSP).
- 这些敏感化模式 (LTP与SSP) 似乎相互排斥.
- 意大利的花生过敏现象与格鲁-撒克逊国家有很大不同.
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