母亲的BMI和3岁以下儿童的过敏 (JECS)
Daisuke Hayashi1,2,3, Emiko Noguchi1,2, Kazushi Maruo4
1Japan Environment and Children's Study Program Office, National Institute for Environmental Studies, Tsukuba, Japan.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
孕前母亲的体重指数 (BMI) 与儿童过敏有关. 较高的母亲BMI增加了喘风险,但降低了儿童的食物过敏风险.
科学领域:
- 儿科过敏和免疫学
- 生殖健康和流行病学
- 公共卫生与营养
背景情况:
- 孕前母亲的体重指数 (BMI) 是影响后代过敏疾病发展的潜在因素.
- 了解这种关系对于识别儿科过敏的早期风险因素至关重要.
研究的目的:
- 调查母亲孕前BMI与儿童医生诊断的喘,食物过敏 (FA) 和亚托皮炎 (AD) 风险之间的联系.
- 分析这些风险在生命的前3年内.
主要方法:
- 利用了来自日本环境和儿童研究的数据,这是一个全国性的出生队列.
- 包括67,204对母婴对,可获得过敏性疾病的数据.
- 使用后勤回归分析来评估关联.
主要成果:
- 增加的母亲BMI与儿童患喘的风险更高有关 (超重:aOR=1.17;肥胖:aOR=1.28).
- 相反,较高的母体BMI与食物过敏风险降低相关,包括牛奶和蛋过敏.
- 在母亲的BMI和亚托皮性皮肤炎风险之间没有发现显著的关联.
结论:
- 孕前母亲的BMI与儿童喘增加和食物过敏患病率降低显著相关.
- 需要进一步的研究来阐明连接母体BMI和儿科过敏疾病发展的潜在生物机制.
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