在口服食品挑战时早期喉反应的评估
Toshinori Nakamura1, Yuki Okada1, Mayu Maeda1
1From the Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
轻微的喉症状可能表明花生过敏的口服食物挑战 (OFC) 是正面的. 然而,这些症状并不足以阻止本研究的挑战.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科过敏 儿科过敏
- 诊断方法 诊断方法
背景情况:
- 开放口服食物挑战 (OFC) 是诊断食物过敏的标准.
- 在OFC过程中不确定的反应可能导致无法确定的诊断结果.
研究的目的:
- 调查轻度喉症状与OFC积极结果之间的关联.
- 评估喉症状是否预测儿童的OFC结果是正面的.
主要方法:
- 对于接受花生,蛋,牛奶或小麦OFC的儿童 (3-15岁) 的医疗记录的回顾性分析.
- 在有或没有喉症状的儿童之间比较OFC结果,反应严重程度和治疗方法.
- 后勤回归分析 (单变量和多变量) 用于评估风险,控制年龄,性别和IgE水平.
主要成果:
- 在198名患者中,有25人经历了轻微的喉症状,最常见的是花生OFC (40%).
- 单变量分析显示,在有症状的儿童中,花生OFC阳性风险增加了5倍 (OR=5.0).
- 多变量分析发现喉症状与任何食物的OFC结果之间没有显著的关联. 过敏反应的发生率没有差异.
结论:
- 轻微的喉症状可以作为阳性花生OFCs的警告信号.
- 这些症状虽然被注意到,但并未被认为足够严重,以保证立即停止口服食品挑战.
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