高血压对二型糖尿病患者皮下细胞核形态交替的影响
Feng Cui1, Zhi-Qiang Ouyang1, Yi-Zhen Zeng1
1Department of Medical Imaging, Laboratory of Brain Function, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Frontiers in endocrinology
|October 2, 2023
概括
高血压 (HTN) 在2型糖尿病 (T2DM) 患者中恶化了大脑变化,特别是影响了丘脑. 管理HTN对于保持T2DM患者的大脑健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 2型糖尿病 (T2DM) 和高血压 (HTN) 是普遍存在的并发症.
- 它们对大脑结构的综合作用,特别是HTN的T2DM患者的皮下细胞核,仍未得到充分研究.
研究的目的:
- 为了研究同时存在的HTN对T2DM患者皮下细胞核形态的影响.
- 为了确定与T2DM和HTN并发症相关的特定大脑变化.
主要方法:
- 招募了92名参与者:36名T2DM,28名T2DM与HTN (T2DMH) 和28名健康对照 (HC).
- 在3D-T1脑图像上利用基于声素的形态测量 (VBM) 和形状分析.
- 评估的临床指标及其与皮层下核交替的相关性.
主要成果:
- 与T2DM患者相比,T2DMH患者的乳头体积减少和形态变化发生了变化.
- 没有HTN的T2DM患者没有表现出与HCs相比显著的皮下改变.
- 在T2DMH患者中,thalamic交替与HTN持续时间负相关.
结论:
- 在T2DM患者中,HTN会加剧皮质下核交替.
- 有效的HTN管理对于减轻T2DM中大脑损伤至关重要.
- 强调解决伴随性疾病对于综合性患者护理的重要性.
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