素缺乏会损害心脏纤维细胞间线粒体功能和心肌收缩性,同时诱导氧化应激
Patrícia Ribeiro do Val Lima1, Karoline Sousa Ronconi1, Elis Aguiar Morra1
1Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES, Brazil.
Frontiers in endocrinology
|October 2, 2023
概括
缺乏会损害心脏收缩性和心脏线粒体功能,特别是在纤维际线粒体中. 这种功能障碍与氧化应激增加有关,可以通过治疗改善.
科学领域:
- 心血管生物学 心血管生物学
- 线粒体生理学线粒体生理学
- 内分泌学 在内分泌学.
背景情况:
- 低丸激素水平与心血管疾病有关.
- 氧化代谢对心肌收缩性至关重要.
研究的目的:
- 研究丸激素缺乏对心脏线粒体亚群 (SSM和IFM) 的影响.
- 评估对心肌收缩性和线粒体功能的影响.
主要方法:
- 雄性Wistar大鼠接受了花切除术以诱导缺乏症.
- 12周后分析了心脏功能和线粒体结构 (SSM和IFM).
- 测量了线粒体功能标志物,蛋白质表达和氧化应激指标.
主要成果:
- 缺乏症降低了心肌收缩性,并影响了线粒体间纤维细胞间氧化酸化.
- 变化包括IFM中线粒体膜潜力和大小的增加,以及减少的p-AMPK-α,PGC-1α和TFAM.
- 在IFM中观察到NADPH氧化酶 (NOX) 和ACE表达的增加,Mn-SOD和催化酶的减少.
结论:
- 素缺乏会损害心脏功能和线粒体间纤维细胞间能量.
- 反应性氧物种,可能来自NOX,与这种功能障碍有关.
- 替代和阿波辛因治疗恢复了心脏和线粒体功能.
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