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通过单细胞转录组学和批量转录组学分析,探索巨细胞在从非典型增生至子宫内膜癌的进展中的作用

Xiaolei Song¹, Re Na¹, Nianghai Peng¹

¹Department of Gynecology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China.

Frontiers in endocrinology

|October 2, 2023

概括

像CDH18和PAGE2B这样的关键基因与子宫内膜癌中的巨M0有关. 这些发现为子宫内膜癌提供了新的治疗点和预后模型.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

子宫内膜癌是一种显著的妇科恶性瘤.
了解瘤微环境,特别是巨细胞透,对于开发有效的治疗方法至关重要.

研究的目的:

通过对巨细胞单细胞分析,识别与子宫内膜癌进展相关的关键基因.
开发基于已识别的基因的子宫内膜癌的诊断和预后模型.

主要方法:

利用TCGA和补充数据集 (GSE201926,GSE173682) 的批量和单细胞RNA测序数据.
进行差异基因表达分析,集群分析和LASSO回归用于诊断建模.
采用CIBERSORT分析来评估与巨细胞亚型 (M0) 的基因关联.

主要成果:

在子宫内膜癌中确定了两种不同的亚型,其中亚型B与细胞代谢有关.
开发了一个使用CDH18,H19,PAGE2B,PXDN和THRB的诊断模型,使得预后有所差异.
发现CDH18和PAGE2B与巨细胞M0.0强烈相关.

结论:

CDH18和PAGE2B可能通过影响巨细胞M0.0来影响子宫内膜癌的发展.
这些基因代表子宫内膜癌的潜在治疗点.
为子宫内膜癌建立了一个新的风险预后模型和柱状图.

关键词:

这就是ScRNA-seqq.非典型的子宫内膜增生症.大量的-seqq.宫内膜癌 (Endometrial Carcinoma) 是一个体内膜癌.巨细胞是一个巨细胞.

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