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在rtPA后的脑内出血中,白血病和中风严重程度得分

Arunnit Boonrod¹, Prompan Tangsakul², Narongrit Kasemsap²

¹Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

BMJ neurology open

|October 2, 2023

概括

白血病 (LA) 和先前的抗凝药治疗与急性缺血性中风血栓溶解后的症状性脑内出血 (sICH) 有关. 这些因素,再加上抗血小板治疗和高密度动脉的迹象,预测疾病的风险.

科学领域:

神经学神经学
脑卒中医学脑卒中医学
放射学放射学是一门学科.

背景情况:

症状性脑内出血 (sICH) 是急性缺血性中风中血栓治疗后的一个重大风险.
白血病 (LA) 已与sICH有关,但其与中风严重程度得分的关联需要进一步澄清.

研究的目的:

调查白血病 (LA),中风严重程度得分和急性缺血性中风患者中症状性脑内出血 (SICH) 的发生之间的关系.
为了确定sICH的独立预测因素,根据基线中风严重程度进行调整.

主要方法:

在急性缺血性中风发作后4.5小时内接受重组组织等离子体激活剂 (rtPA) 的504名成年患者的回顾性分析.
使用后勤回归分析来确定sICH的预测因素,考虑LA,高密度动脉征兆和先前的抗血小板/抗凝药治疗等因素.

主要成果:

症状性脑内出血 (sICH) 在8.92% (45/504) 的患者中发生.
独立预测SICH的预测因素包括先前的抗血小板治疗,先前的抗凝药治疗,白血病 (LA) 的存在和高密度动脉信号.
之前的抗凝剂治疗显示了最高的调整几率比率 (5.08),而LA的调整几率比率为2.52.

结论:

白血病 (LA),高密度动脉征兆以及先前的抗血小板和抗凝药疗法与血栓溶解后的症状性脑内出血 (sICH) 有关.
这些发现突出了患者的特定特征,这些特征可能会增加rtPA治疗后sICH的风险.
需要进一步的研究来验证这些关联,并完善SICH的风险预测模型.

关键词:

一次性中风中风中风中风中风

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