高密度脂蛋白胆固醇和多发性骨髓瘤:一个系统的审查和元分析
Anastasios Makris1,2, Antonia Pagkali1, Emmanouil Nikolousis1
1School of Medicine, European University Cyprus, Nicosia, Cyprus.
Atherosclerosis plus
|October 2, 2023
概括
多发性骨髓瘤患者的高密度脂蛋白胆固醇 (HDL-C) 和其他脂质标记物显著降低. 这些发现表明,将脂质资料纳入多发性骨髓瘤患者评估中至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床生物化学 临床生物化学
背景情况:
- 多发性骨髓瘤 (MM) 是一种具有复杂病理生理学的血液性恶性瘤.
- 在各种癌症中,越来越多地认识到脂质代谢的改变.
- 高密度脂蛋白胆固醇 (HDL-C) 和MM之间的特定关联需要进行系统的调查.
研究的目的:
- 对HDL-C和MM之间的关联进行系统审查和元分析.
- 评估HDL-C和其他脂质参数在MM患者中的作用.
- 在多发性骨髓瘤的背景下,综合现有关于脂质谱的证据.
主要方法:
- 在PubMed和Cochrane图书馆数据库中进行系统的文献搜索,截至2022年9月.
- 包括前性和后性研究,检查MM患者的HDL-C.
- HDL-C的定性合成和元分析意味着MM病例和对照之间的差异.
主要成果:
- 系统性审查包括14项研究 (895名MM患者).
- 对10项研究 (17,213名参与者) 的分析显示,与对照组相比,MM患者的HDL-C水平显著降低 (MD: -13.07 mg/dl).
- 总胆固醇 (TC) 和阿波利波蛋白AI (apoA-I) 的显著下降也被观察到,但LDL-C或甘油三的显著下降并没有.
结论:
- 在多发性髓瘤患者中,HDL-C,TC和apoA-I水平显著降低.
- 这些脂质谱的变化值得在MM的临床评估和管理中加以考虑.
- 进一步的研究可能会阐明这些脂质变化对MM的预后和诊断影响.
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