功能性连接体指纹在整个寿命的指纹
Frédéric St-Onge1,2, Mohammadali Javanray1,2, Alexa Pichet Binette3
1Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, Canada.
大脑的功能连接提供了一个独特的"连接体指纹",用于各个年龄段的个人识别. 这种"自我识别能力"随着年龄的增长呈现出一个U形的模式,在中年时代下降,然后在老年人中恢复.
科学领域:
- 神经科学是一个神经科学.
- 脑部成像 脑部成像
- 衰老研究研究 衰老研究
背景情况:
- 大脑的功能架构随着年龄的增长而系统地发生变化.
- 功能连接 (FC) 可以创建独特的"连接指纹"用于个人识别.
- 以前的研究证实了年轻人的指纹,但寿命可靠性是未知的.
研究的目的:
- 调查功能连接指纹在人类寿命的可靠性.
- 为了确定个人识别能力如何随着年龄的增长而变化.
主要方法:
- 将功能连接指纹框架应用于18-89岁的大群 (n=483) (剑桥衰老和神经科学中心).
- 分析了功能性MRI数据,以评估"自我识别" (个人内的一致性) 和"他人识别" (个人之间的区别性).
主要成果:
- 在独立的功能性MRI扫描中,个人在整个生命周期内都可靠地"指纹".
- "自我识别"和"他人识别"遵循U形分布,从早期成年到中年减少,然后在老年时增加.
- 促进自我识别能力的大脑区域因人而异,不局限于特定网络;自我识别能力也与区域大脑体积相关.
结论:
- 使用功能连接的个人身份识别在整个生命周期中被保留.
- 这种"连接体指纹"的强度随着年龄的增长而变化非线性,显示出U形轨迹.
- 这些发现突显了个体大脑连接体的持久独特性,尽管与年龄相关的变化.
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