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在戈勒斯坦队列研究中,可归因于使用片和吸烟烟的癌症事件
Karine Alcala1, Hossein Poustchi2, Vivian Viallon3
1Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC - WHO), Lyon, France.
EClinicalMedicine
|October 2, 2023
概括
片使用和吸烟显著导致癌症负担. 公共卫生倡议的目标应该是减少这两种物质的使用,以降低癌症发病率.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 片消费已被公认为致癌物质,但其对整体癌症负担的具体影响尚不清楚.
- 在某些地区片使用率很高,需要了解片对癌症的贡献.
- 烟草吸烟是众多癌症的已知风险因素.
研究的目的:
- 量化单独归因于片使用的癌症比例.
- 评估片使用和吸烟对癌症发病率的综合影响.
- 评估与片和烟草相关的癌症的人口归因分数 (PAFs).
主要方法:
- 一项前性队列研究,涉及50 045名伊朗成年人 (2004-2022年).
- 利用比例危险回归模型来分析物质使用和癌症诊断之间的关联.
- 针对各种癌症类型和物质使用组合的计算人口归因分数 (PAFs).
主要成果:
- 仅片使用就占了与片有关的癌症的35%;仅吸烟就占了与烟草有关的癌症的9%.
- 片和香烟的联合使用显著增加了喉,喉,肺和膀癌的风险 (PAFs 50%-77%).
- 片和/或香烟使用与所有癌症的13%,片相关癌症的58%,烟草相关癌症的15%有关.
结论:
- 片消费和吸烟是导致该人口癌症负担的主要原因.
- 有针对性的预防政策和公众宣传活动对于减少这些与物质相关的癌症的发生率至关重要.
- 建议采取旨在减少片和香烟使用的干预措施,以减轻癌症风险.
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