在移植候选人的疫苗接种
Kiran Gajurel1, Tue Ngo1, Robert T Fairman2
1Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC.
Transplantation direct
|October 2, 2023
概括
移植的候选人显示了较低的针对关键疾病的先前疫苗接种率. 然而,在符合条件的候选人中,接种疫苗的比例很高,这表明免疫接种后评估有所改善.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 移植 (KT) 候选人往往表现为推疫苗的历史低免疫率.
- 评估这一脆弱群体的疫苗接种情况和接种率对于预防移植后感染至关重要.
研究的目的:
- 评估基线疫苗接种率和移植候选人的基本疫苗的血清阳性.
- 为了确定在移植前评估期间符合条件的候选人中接种疫苗的情况.
主要方法:
- 在2020年1月至2020年12月期间评估的150名KT候选人 (≥18岁) 的回顾性研究.
- 评估了先前对破伤风,白喉,百日咳,肺炎球菌 (PCV13,PPSV23) 和复合疫苗的疫苗接种史.
- 使用IgG抗体作为免疫标记物,测量了A型肝炎,B型肝炎,麻疹,,红疹和水的阳性.
主要成果:
- 观察到基线疫苗接种率较低,只有11%的人接种了破伤风, diphtheria, pertussis, PCV13, PPSV23或疹疫苗.
- 血清阳性率各不相同:甲型肝炎 (30%),乙型肝炎 (66%),麻疹 (88%),疹 (78%),红疹 (90%),以及水 (96%).
- 只有5%的候选人有完整的免疫或血清阳性;肝炎A疫苗的拒绝值得注意 (16%的符合条件).
结论:
- 移植候选人对几个关键疫苗的免疫和血清阳性水平较低.
- 尽管基线率较低,但符合条件的候选人中总体接种疫苗率很高,这表明成功的移植前免疫策略.
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