阿片类药物和免疫检查点抑制剂在三阴性乳腺癌中差异调节共同的免疫网络
Joseph R Scarpa1, Giacomo Montagna2, George Plitas2
1Department of Anesthesiology, Weill Cornell Medicine, New York, NY, United States.
Frontiers in oncology
|October 2, 2023
概括
阿片类药物可能通过反对免疫基因表达来降低三阴性乳腺癌 (TNBC) 免疫疗法的有效性. 胺是一种非阿片类药物,似乎与免疫疗法没有相互作用,为癌症疼痛管理提供了潜在的替代方案.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物是癌症疼痛的标准,但可能会干扰免疫检查点抑制 (ICI) 免疫疗法.
- 阿片类药物-ICI相互作用的机制尚不清楚,特别是在三阴性乳腺癌 (TNBC) 中.
- 这项研究调查了阿片类药物和胺对TNBCRNA表达的影响以及潜在的ICI相互作用.
研究的目的:
- 确定阿片类药物可能降低TNBC中ICI疗效的机制.
- 为了比较胺,一种非阿片类止痛药,对于潜在的ICI相互作用.
- 在TNBC中分析由阿片类药物,胺和ICI调节的RNA表达途径.
主要方法:
- 对286名TNBC患者的瘤RNA表达和临床病理学数据的分析.
- 从多模式数据集中提取和分析药物诱导的RNA表达特征.
- 估计ICI,阿片类药物和胺对TNBC的RNA表达效应.
主要成果:
- 确定了与TNBC病变发生和预后相关的CD8+T细胞RNA表达网络.
- 在这个网络中,阿片类药物 (吗啡) 和抗PD-L1 ICI 调节了 RNA 表达的相反方向.
- 与抗PD-L1疗法相比,胺在RNA表达效应上的重叠很小.
结论:
- 阿片类药物和ICI可能针对TNBC中的共享免疫网络,以对抗性调节基因表达.
- 有证据表明,胺与ICI的相互作用并不像阿片类药物一样.
- 这些发现表明,在接受免疫治疗的患者中,对疼痛管理策略的潜在影响.
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