相关实验视频

Updated: Jul 15, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

病例报告:Sintilimab诱导的史蒂文斯-约翰逊综合征在患有晚期肺腺癌的患者中

Xueqin Li¹, Guanghui Li¹, Diangang Chen¹

¹Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing, China.

Frontiers in oncology

|October 2, 2023

概括

免疫检查点抑制剂 (ICI) 可以引起严重的皮肤反应,如史蒂文斯-约翰逊综合征 (SJS). 这一案例突显了SJS在一个肺癌患者治疗sintilimab,与独特的PD-L1表达模式观察到.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
与皮肤相关的不良事件在ICI中很常见,包括像史蒂文斯-约翰逊综合征 (SJS) 这样的严重反应.
了解ICI诱导的SJS的机制对于患者安全至关重要.

研究的目的:

报告一种罕见的史蒂文斯-约翰逊综合征 (SJS) 病例,该病例发生在患者中,该患者接受了辛蒂利马布和帕克利塔塞尔治疗.
为了研究这个患者皮肤病变的免疫和分子特征.
为了比较观察到的PD-L1表达模式与ICI诱导SJS的先前发现.

主要方法:

一个76岁的男性患有转移性肺腺癌的病例报告.
患者在化疗/放射治疗后接受了sintilimab和paclitaxel脂肪体.
皮肤活检分析免疫细胞透 (CD4,CD8) 和PD-L1表达.

主要成果:

该患者患有史蒂文斯-约翰逊综合征 (SJS),涉及广泛的皮肤和粘膜表面.
皮肤活检显示了CD4和CD8阳性T淋巴细胞的透.
在皮肤的腺体和基底层观察到明显的PD-L1表达,与表皮皮质角质细胞表达不同.

结论:

辛提利马布与帕克利塔克塞尔脂酶组合可以诱导严重的史蒂文斯-约翰逊综合征 (SJS).
在皮肤腺和基底层观察到的PD-L1表达是ICI诱导SJS的一个独特发现.
需要进一步的研究来阐明ICI诱导的SJS的具体机制和PD-L1局部化的作用.

关键词:

史蒂文斯-约翰逊综合征史蒂文斯-约翰逊综合征不良事件不良事件不良事件案例报告案例报告免疫疗法免疫疗法这种感觉是不可思议的.

更多相关视频

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...