单核酸多态和状细胞疾病相关的疼痛:一个系统的审查
Gina M Gehling1, Keesha Powell-Roach2, Diana J Wilkie1
1College of Nursing, University of Florida, Gainesville, FL, United States.
Frontiers in pain research (Lausanne, Switzerland)
|October 2, 2023
概括
遗传变异影响状细胞疾病 (SCD) 的疼痛. 本综述综合了关于单核酸多态和SCD疼痛的研究,强调需要更强大的研究来推进精确健康.
科学领域:
- 遗传学和精准医学 遗传学和精准医学
- 血液学 血液学 血液学
- 疼痛研究 疼痛研究
背景情况:
- 人们推测,遗传变异,特别是单核酸多态 (SNP),会影响个人的疼痛经历.
- 现有的关于SNP和状细胞疾病 (SCD) 相关疼痛的研究缺乏综合,阻碍了精确健康计划.
- 本系统性审查解决了关于与SCD疼痛相关的SNP现有知识的巩固的需要.
研究的目的:
- 系统地审查和综合有关单核酸多态 (SNP) 与状细胞疾病 (SCD) 相关疼痛的科学文献.
- 通过了解SCD疼痛的遗传贡献的当前证据状态,为未来的精确健康研究提供信息.
主要方法:
- 在2021年12月至2022年4月期间,按照PRISMA指南进行了系统的文献搜索.
- 搜索了包括PubMed,Web of Science,CINAHL和Embase在内的数据库,查找1998年至2022年出版的同行评审文章.
- 包括报告SNP与SCD相关疼痛结果之间的关联的文章;在查后保留了22篇文章.
主要成果:
- 搜索结果为215篇文章,其中22篇文章在重复删除和选后符合纳入标准.
- 该领域在很大程度上是探索性的,只有三项研究具有足够的统计能力来进行遗传关联分析.
- 包括的研究重点是急性疼痛 (n=22),其中9项还研究了慢性疼痛;参与者的人口统计数据从儿童到患有SCD的成年人之间有所不同.
结论:
- 目前的证据将遗传变异与急性和慢性SCD疼痛联系起来,依赖于适度的候选基因研究.
- 研究中观察到的效果大小和方向为设计未来研究提供了宝贵的见解.
- 进一步进行高功率的,以假设为导向的研究对于复制发现和推进SCD疼痛管理的精确健康策略至关重要.
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