支气管炎的临床结果中的年龄和呼吸道同胞性病毒病因
Rosa Rodriguez-Fernandez1,2, María Isabel González-Sánchez1,2, Jimena Perez-Moreno1,2
1Department of Pediatrics, Hospital Infantil Gregorio Marañón, Madrid, Spain.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
呼吸道综合体病毒 (RSV) 支气管炎在6个月以下的婴儿中更为严重. 与非RSV原因相比,这种RSV感染增加了住院,重症监护和需要呼吸支持的风险.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 呼吸道综合体病毒 (RSV) 是幼儿支气管炎的主要原因.
- 对RSV支气管炎流行病学,临床特征和风险因素的准确数据对于新的干预措施至关重要.
- 了解疾病的严重程度是管理住院婴儿的关键.
研究的目的:
- 确定西班牙五年来住院儿童急性支气管炎的流行病学.
- 为了比较RSV和非RSV支气管炎之间的临床表现.
- 为了确定幼儿严重支气管炎的危险因素.
主要方法:
- 追溯审查医疗记录的2岁以下的儿童住院治疗支气管炎 (2015-2019).
- 用于识别疾病严重程度预测指标的多变量模型.
- 严重程度由停留时间 (LOS),PICU入院和需要高流量鼻腔管 (HFNC) 定义.
主要成果:
- 1437名儿童住院;RSV比例从60%增加到65% (P=.03).
- RSV支气管炎患者的年龄较小 (中位数为3个月) 比非RSV患者 (中位数为4个月).
- 婴儿<6个月RSV支气管炎的严重程度增加 (较长的LOS,更多的PICU入院,HFNC,IV液体,肠道养). 年龄小于6个月和RSV病因独立预测PICU入院,HFNC和更长的LOS.
结论:
- 在幼儿的RSV和非RSV支气管炎之间存在疾病严重程度的显著差异.
- 患有RSV支气管炎的6个月以下的婴儿代表了潜在的低于最佳免疫力的脆弱群体.
- 这些发现凸显了针对严重RSV疾病高风险婴儿的有针对性的预防策略的需要.
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