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亚洲和中欧敏感患者的IgE反应模式揭示了初级敏感化过敏原来源的差异

Irene Mittermann¹, Christian Lupinek¹, Sandra Wieser¹

¹MacroArray Diagnostics, Vienna, Austria.

The journal of allergy and clinical immunology. Global

|October 2, 2023

概括

(CR) 敏感性在地理位置上有所不同,香港患者表现出真正的CR过敏,而奥地利人则没有. 分子分析揭示了不同的IgE反应模式,并确定了热氨酸作为潜在的喘生物标志物.

科学领域:

过敏原免疫疗法免疫疗法
分子过敏学分子过敏学
免疫学免疫学免疫学

背景情况:

(CR) 敏感性流行率和过敏性作为过敏症状的触发因素在不同地理区域有很大的差异.
了解这些区域差异对于有效的过敏管理至关重要.

研究的目的:

为了在香港 (HK) 和奥地利之间比较CR敏感患者的分子IgE反应性概况.
确定这些不同人群中引起过敏反应的主要敏感剂.

主要方法:

通过皮肤刺伤测试和/或IgE对CR提取物的反应性来评估过敏原敏感性.
多重检测被用来分析分子IgE反应性特征对CR,家尘 (HDM),贝类和其他昆虫过敏原.

主要成果:

室内灰尘 (HDM) 是香港和奥地利队伍的主要敏感剂.
虽然45%的香港患者表现出真正的CR敏感性,但奥地利队列中没有人表现出这种情况. 对其他昆虫和贝类的交叉敏感性在香港很常见,与氨酸和氨酸激酶有关.
托罗普米奥辛 (Per a 7) 与喘有显著的相关性,而Bla g 4 (利波卡林) 仅在香港患者中检测到.

结论:

分子分析揭示了香港和奥地利的CR敏感过敏患者之间主要敏感剂和IgE反应模式的显著差异.
来自美国 (Per a 7) 的托罗普米奥辛成为更严重的呼吸道过敏症状,特别是喘的潜在生物标志物.

关键词:

组件解决的诊断组件解决的诊断氨酸酶是一种阿尔金氨酸酶.的敏感化活动交叉反应性交叉反应性可食用昆虫的敏感化微阵列是微阵列中的一个.多重测试多重测试多重测试主要感应器主要感应器这种药物被称为tropomyosin.

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