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治疗儿童过敏性蛋过敏的口服免疫治疗的长期结果
Koki Sasamoto1,2, Noriyuki Yanagida1,3, Ken-Ichi Nagakura1
1Department of Pediatrics, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
对患有过敏性蛋过敏的儿童进行长期口服免疫疗法 (OIT) 显著增加了成功摄入3100毫克蛋蛋白的比率. 这种治疗加速了免疫变化,超过一半的患者在三年内达到耐受性.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 食物过敏研究 食物过敏研究
背景情况:
- 对于患有过敏性蛋过敏的儿童的长期口服免疫疗法 (OIT) 存在有限的研究.
- 对蛋的过敏反应对健康构成重大风险,需要有效的长期管理策略.
研究的目的:
- 研究被诊断患有过敏性蛋过敏的儿童OIT的长期结果.
- 评估持续的OIT在实现持续口服食品挑战 (OFC) 耐受性的有效性和安全性.
主要方法:
- 纳入了年龄≥5岁且有过敏反应过敏史的儿童.
- OIT涉及每天摄入逐渐增加的蛋蛋白剂量,达到1000毫克,每年的OFC为3100毫克.
- 一个没有OIT的历史控制组每年进行OFC.
主要成果:
- 与对照组相比,OIT组的OFC通过率显著更高 (3100毫克蛋蛋白比对照组高55%vs3年5%).
- 经过3年时间,OIT导致蛋白和卵菌特异性IgE水平降低,并增加了特异性IgG和IgG4水平.
- 副作用是最小的,有0.04%的OIT参与者在家中经历过敏反应.
结论:
- 长期的OIT有效地加快了患有过敏性蛋过敏的儿童的免疫变化.
- 在接受长期OIT治疗的参与者中,一半的参与者能够耐受3100毫克的蛋蛋白.
- 在儿童群体中,OIT提供了一种可行的治疗选择,用于治疗严重的蛋过敏.
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