在心脏手术后,前列红素复合度与静脉血栓形成的关联:一个病例对照研究
Qiaowei Zheng1, Liting Zhang1, Tingting Liu1
1Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Frontiers in cardiovascular medicine
|October 2, 2023
概括
在心脏外科手术中,外科手术期间输注前热血素复合物缩剂 (PCC) 与术后静脉血栓形成的风险增加没有显著关联. 建议进行进一步的随机对照试验以证实这些发现.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 外科手术的结果
背景情况:
- 凝血复合物缩剂 (PCC) 用于增强凝血和控制出血.
- 在心脏手术后,外科手术期间PCC输液和静脉血栓形成之间的关联需要进一步调查.
研究的目的:
- 评估外科手术期间输注前热血素复合物缩剂 (PCC) 与心脏手术患者手术后静脉血栓形成的风险之间的关联.
主要方法:
- 进行了一项病例控制研究,涉及2021年接受心脏手术的161名患者.
- 使用多变量逻辑回归和分层分析来评估PCC输注和静脉血栓症之间的相关性,并对混因素进行调整.
主要成果:
- 在161名患者中,37名 (23.0%) 患有静脉血栓症.
- 最初的分析表明,PCC输注显著增加了静脉血栓的风险 (OR:3.10),但经过对混因子进行调整后,这种关联没有显著意义 (模型2 OR:1.76,P=0.3317).
- 在完全调整的模型中观察到一个边际显著的关联 (模型3OR:0.03,P=0.0637).
结论:
- 在心脏外科手术中,术后PCC输液与术后静脉血栓形成的风险增加没有显著关联.
- 需要进一步的随机对照试验才能确定确切的因果关系.
相关概念视频
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
Venous Thrombosis I: Introduction
12
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
12
Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
741
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
741


