维生素D作为住院COVID-19患者负面结果的预测因素:一项观察性研究
Volodymyr Bogomaz1, Sofiia Shatylo1
1Department of Internal Medicine, Faculty of Dentistry Bogomolets National Medical University.
概括
血清维生素D缺乏可能不是严重COVID-19结果的唯一预测因素. 低维生素D水平显示出增加呼吸支持需求的趋势,但在调整后,这并不显著.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 关键护理医学 关键护理医学
背景情况:
- 血清维生素D缺乏被假设与COVID-19患者的不良临床结果相关.
- 了解这种关联对于管理住院COVID-19病例至关重要.
研究的目的:
- 为了调查血清维生素D水平与乌克兰住院COVID-19患者的负面结果之间的关联.
- 为了确定低维生素D水平是否预测死亡率增加或需要呼吸辅助.
主要方法:
- 一个单一中心的观察性研究包括70名住院COVID-19患者,通过PCR确认.
- 患者被分为充足 (≥30 ng/ml) 和低 (<30 ng/ml) 血清维生素D组.
- 记录了包括死亡,呼吸辅助和C反应性蛋白水平在内的结果.
主要成果:
- 维生素D水平较低的患者的C反应性蛋白水平较高 (26.14 mg/L与13.43 mg/L).
- 维生素D的低水平最初与需要呼吸辅助的几率增加有关 (OR 2.925).
- 这种关联在调整年龄,性别和并发症后失去了统计意义.
结论:
- 维生素D对COVID-19死亡率和呼吸系统支持的预测作用可能被高估了.
- 较低的维生素D水平可能会影响COVID-19的结果,在患有并发病的老年患者中更为显著.
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