严重COVID-19的老年患者在不同的营养方法下肠道微生物群的变化及其与预后的关系
Jiawei Zhang1,2,3,4, Jiaxin Deng1,2,3,4, Juan Li1,2,3,4
1Department of General Surgery (Endoscopic Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
肠道营养 (EN) 与肠道营养 (PN) 相比,改善了老年COVID-19患者的治疗结果. 晚期瘤与更高的并发症,死亡率和有害的肠道细菌 (如Enterococcus faecium) 相关,影响了预后.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染呈现异质的临床进展,不成比例地影响老年人.
- 营养和肠道微生物群之间的相互作用越来越多地被认为对疾病结果的作用.
- 了解这些关联对于优化弱势老年人群的护理至关重要.
研究的目的:
- 评估不同营养支持干预措施对COVID-19老年患者预后的影响.
- 调查便微生物群组成与该患者组的临床结果之间的关系.
- 评估微生态变化对预后结果的影响.
主要方法:
- 一组71名患有严重COVID-19的老年患者被分为肠道营养 (EN) 和肠道营养 (PN) 组.
- 收集和分析了关于并发症和60天死亡率的临床数据.
- 分析了便微生物群的组成,并使用后勤回归和斯皮尔曼相关性确定了与临床结果的相关性.
主要成果:
- 与EN组相比,PN组的并发症率 (69.6%) 和60天死亡率 (30.4%) 显著更高 (分别为10.4%和2.1%).
- 在PN组中观察到*Enterococcus_faecium*和*Pseudomonas_aeruginosa*的丰度增加.
- *Enterococcus_faecium*的丰度与预后不佳正相关,而 *Ruminococcus*的丰度显示出负相关.
结论:
- 营养支持策略显著影响老年COVID-19患者的肠道菌群组成和临床结果.
- 亲肠道营养与增加的*Enterococcus_faecium*丰度和较差的临床结果有关.
- 以微生物组为中心的干预措施有可能在接受不同营养支持的老年人中管理COVID-19.
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