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Updated: Jul 15, 2025

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由AURKA抑制剂诱导的PD-L1上调会损害抗瘤免疫反应

Bi Meng1,2,3, Xuan Zhao1,2,3, Shuchang Jiang4

  • 1Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Frontiers in immunology
|October 2, 2023
PubMed
概括

AURKA抑制剂MLN8237增加PD-L1的表达,可能增强瘤免疫疗法. 在临床前模型中,将MLN8237与抗PD-L1抗体结合,显著降低了瘤体积,并促进了T细胞透.

关键词:
这是一种AURKA抑制剂.MLN8237 没有任何法律规定.在PD-L1中.在p-STAT3中,有针对性的药物药物.瘤免疫疗法 免疫疗法

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