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一场基于证据的关于COVID-19表观遗传学和免疫发生的辩论

Claudio Napoli^1,2, Enrico Coscioni³, Ugo Trama⁴

¹Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Naples, Italy.

Current research in immunology

|October 2, 2023

概括

免疫衰老,或免疫系统衰老,增加了老年人COVID-19的严重程度. 涉及的表观遗传变化包括DNA低甲基化和基因组修饰,但针对这些的疗法可能会改善结果.

科学领域:

免疫学免疫学免疫学
老年学是指老年学的学科.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

免疫衰老,即免疫系统的衰老,会损害老年人对COVID-19等感染的反应.
在老年人中,COVID-19的严重程度是异质的,受遗传和表观遗传因素的影响,这些因素有助于免疫发生.
特定的表观遗传变化,如ACE2促进体低甲基化和基因素H3素化,与老年人更糟糕的COVID-19结局有关.

研究的目的:

探索表观遗传敏感事件在老年人COVID-19严重性和死亡率增加中的作用.
讨论潜在的向疗法,以抵消免疫衰变并改善COVID-19的结果.
要突出表观遗传衰老,端粒长度和老年COVID-19患者的预后生物标志物之间的关联.

主要方法:

关于老年人群中免疫衰变,表观遗传学和COVID-19严重性的现有文献的综述.
对表观遗传机制的分析,包括DNA甲基化 (表观遗传钟) 和基因组修饰.
检查临床数据,将表观遗传衰老,端粒缩短,淋巴缺血和COVID-19结局联系起来.

主要成果:

加速表观遗传衰老和端粒缩短与老年COVID-19患者的淋巴缺血和不良预后有关.
患有较轻度COVID-19症状的百岁老人表现出较年轻的表观遗传年龄.
在老年人中,ACE2促进体和基因素H3氨化低甲基化与COVID-19严重程度的增加有关.

结论:

表观遗传修饰在老年人中严重的COVID-19和死亡率的风险增加中发挥着重要作用.
向疗法,包括那些有间接表观遗传干扰的疗法 (例如,他类药物,白醇),显示出对抗免疫衰变的希望.
了解这些表观遗传因素为开发新型预后生物标志物和老年COVID-19患者的治疗策略提供了潜力.

关键词:

年长的老人.基因表观衰老基因表观衰老基因表观衰老免疫衰变的起源预测性生物标志物预测性生物标志物严重的COVID-19 疾病有针对性的治疗.端粒长度端粒长度端粒长度

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