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左心室菌株与2型糖尿病患者心血管风险因素之间的关联:一项受控横截面研究
Nguyen Nguyen Trang1,2, Nguyen Anh Vu1, Le Van Chi1
1Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue city, Vietnam.
概括
2型糖尿病患者心脏功能减弱,特别是全球纵向应变和全球周围应变. 这些减少与糖尿病患者常见的心血管风险因素有关.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 心血管并发症是糖尿病患者死亡的主要原因.
- 斑点跟踪回声心电图 (STE) 能够早期检测左心室缩功能障碍,即使射出分数正常.
- 2型糖尿病 (T2DM) 是心血管疾病的重要危险因素.
研究的目的:
- 在2型糖尿病患者中使用STE评估左心室缩功能.
- 调查 STE 衍生的心肌张力参数与 T2DM 中心血管风险因素之间的关系.
主要方法:
- 进行了一项受控的横截面描述性研究.
- 包括150名参与者:75名T2DM患者和75名健康对照.
- 斑点跟踪回声心脏图被用来测量全球纵向应变 (GLS) 和全球周围应变 (GCS).
主要成果:
- 与对照组相比,T2DM患者的GLS (-17.02±3.06%) 和GCS (-29.04±6.39%) 显著降低 (p<0.05).
- GLS显示了与静缩血压 (r=0.3),静缩血压 (r=0.2),空腹血葡萄糖 (r=0.5),HbA1c (r=0.2) 和总胆固醇 (r=-0.25) (p<0.05) 的相关性.
- GCS与静缩血压 (r=0.2),静缩血压 (r=0.2) 和高血压 (r=-0.3) (p<0.05) 相相关.
结论:
- 患有2型糖尿病的患者表现出左心室缩功能受损,以减少GLS和GCS为证.
- 在T2DM中GLS和GCS的下降与心血管风险因素有关,包括高血压,血糖控制不佳,BMI升高和脂质失调.
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