形虫通过肌肉氧化代谢升高调节肌肉再生并增强功能
Chang-Lim You1, Sang-Jin Lee2, Jinwoo Lee2
1Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.
International journal of biological sciences
|October 2, 2023
概括
查加 (Inonotus obliquus) 提取物显示,它有望防止肌肉消耗. 它通过激活关键细胞通路来增强肌肉再生和新陈代谢,提供一种天然方法来对抗与年龄相关的肌肉损失.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨肌肉消耗与衰老和疾病有关,增加心血管问题,代谢综合征和炎症的风险.
- 目前的研究重点是开发改善肌肉新陈代谢和功能的药物.
- (chaga mushroom) 是一种传统的民间药物,但它对肌肉健康的影响尚未被探索.
研究的目的:
- 为了研究伊诺诺托斯斜的提取物对肌肉再生和新陈代谢的潜在益处.
- 为了探索Inonotus obliquus在肌肉健康中的潜在分子机制.
主要方法:
- C2C12神经细胞被用Inonotus obliquus提取物治疗,使用或不使用德克萨米他.
- 对提取物中已识别的化学成分进行了网络药理学分析.
- 在体内研究中,在心脏毒素诱导的肌肉损伤后,用Inonotus obliquus提取物治疗小鼠.
主要成果:
- 在实验室中,Inonotus obliquus提取物促进了肌体分化,并减少了德甲诱导的肌管缩.
- 网络分析预测了参与肌形成和再生的AKT依赖性途径.
- 在体内,提取物增强了肌肉再生,增加了肌肉干细胞的增殖和分化,增加了线粒体含量,并通过PGC-1α诱导促进了氧化代谢.
结论:
- 伊诺诺图斯 obliquus 提取物表明对肌肉再生和新陈代谢有有益影响.
- 提取物激活了AKT信号传递,抑制了肌肉特定的无素E3链酶.
- 状 (Inonotus obliquus) 显示出作为一种天然剂的潜力,可以增强肌肉再生能力和氧化代谢,从而防止肌肉衰竭.
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