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印度的翻译性凝聚膜膜生物学网络 (I-TANGIBLE):设计和方法

Kavita Yadav¹, Raja Ramachandran², Vinod Kumar³

¹Chronic Kidney Disease, George Institute for Global Health India, New Delhi, India.

Indian journal of nephrology

|October 2, 2023

概括

这项研究建立了印度翻译性淋巴细胞膜生物学网络 (I-TANGIBLE),以改善对主要淋巴细胞疾病的理解和治疗,包括IgA脏病和焦点细分淋巴细胞硬化.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
翻译研究是翻译研究.
临床流行病学临床流行病学

背景情况:

原发性球细胞疾病是印度慢性病 (CKD) 的重要原因,占病例的六分之一.
目前的治疗因缺乏了解疾病机制和临床过程和治疗反应的预测标记而受到限制.
对于研究这些疾病和改善患者治疗结果的结构化方法至关重要.

研究的目的:

建立一个研究人员的合作网络,专注于印度的淋巴细胞疾病.
系统地收集临床和生物数据,以了解疾病机制,临床结果和治疗反应.
为了促进对患者的鉴定和招募用于临床试验的初级质球膜疾病.

主要方法:

一个前性的观察性研究设计.
招募18岁以上的患者,有活检证明的最小变化性疾病,焦点细分球炎,膜性病,IgA病或膜增殖性球炎.
排除患有严重功能障碍 (eGFR <15毫升/分钟/1.73米2>3个月),移植接受者,活跃恶性瘤或活跃病毒感染 (乙型肝炎/乙型肝炎,艾滋病毒) 的患者.
收集详细的临床信息,血液和尿液样本进行储存,并与临床随访保持一致.

主要成果:

这项研究旨在在多个地点确定质细胞疾病的疾病负担.
它将确定常见的球细胞疾病的治疗模式.
它将调查中长期的结果,包括缓解,复发,以及估计质过率 (eGFR) 下降的速度.

结论:

I-TANGIBLE网络将提供关于印度初级球细胞疾病流行病学和临床过程的关键数据.
它将建立一个用于翻译研究和临床试验的基础设施.
预计这些发现将有助于更好地了解和管理这些衰弱的病.

关键词:

焦点细分型球膜炎 (FSGS)纵向队列是一种纵向队列.膜增殖性全球球膜炎 (MPGN) 是一种膜性脏病 (MN) 的发生.最小变化的疾病 (MCD)

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