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Updated: Jul 15, 2025

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
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Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

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一个TrkB和TrkC部分激动剂恢复了突触功能的缺陷,并在晚期阿尔茨海默病小鼠模型中促进了活动依赖的突触和微质转录变化

Amira Latif-Hernandez, Tao Yang, Robert Raymond-Butler

    bioRxiv : the preprint server for biology
    |October 2, 2023
    PubMed
    概括

    一种新型化合物PTX-BD10-2 (BD10-2) 在阿尔茨海默病 (AD) 鼠标模型中改善了记忆和突触功能. 这种TrkB/C受体激素减轻了粉样β的毒性影响,为AD提供了潜在的治疗益处.

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