免疫记忆塑造了人类对H2N2疫苗接种的多克隆抗体反应
Yuhe R Yang1,2, Julianna Han1, Hailee R Perrett1
1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
bioRxiv : the preprint server for biology
|October 2, 2023
概括
流感H2N2构成了全球性的威胁. 这项研究揭示了先前的H2暴露如何塑造对H2血凝素疫苗的抗体反应,影响免疫记忆和疫苗的有效性.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 流感A型病毒亚型H2N2导致了1957年的流行病,并仍然是一个全球健康问题.
- 一个I阶段临床试验评估了H2暴露和H2暴露的成年人中的ferritin纳米颗粒H2血素疫苗.
研究的目的:
- 描述H2疫苗接种引起的免疫记忆的结构和生化方面.
- 分析疫苗接种后多克隆血清抗体反应的范围和多样性.
主要方法:
- 在接种疫苗后对抗体表位的时间映射.
- 低温电子显微镜 (cryo-EM) 和单克隆B细胞隔离.
- 抗体反应的生物化学特征.
主要成果:
- 之前的H2暴露增强了对可变头部血凝素域的反应.
- 无辜的个体表现出最初的反应主要是由针对保存表位的抗体主导的.
- 克里奥-EM确定了向保存表位的交叉反应性抗体,包括受体结合部位和中间结点.
结论:
- 预先存在的流感暴露显著影响血清抗体对H2疫苗接种的反应.
- 了解这些影响对于开发有效的流感疫苗至关重要.
- 已识别的保存表位代表了通用流感疫苗的潜在目标.
更多相关视频
04:47A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
7.8K
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
1.9K
相关概念视频
Immunological Memory
652
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
652
Cells of the Adaptive Immune Response
1.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.0K
Vaccinations
44.6K
Overview
44.6K
Cross-reactivity
31.2K
Overview
31.2K
Humoral Immune Responses
72.9K
Overview
72.9K
Immune Response Against Viral Pathogens
811
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
811
