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Updated: Jul 15, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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设计的内细胞酶触发蛋白调解有针对性的降解.

Buwei Huang1,2,3, Mohamad Abedi1,2, Green Ahn4

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

bioRxiv : the preprint server for biology
|October 2, 2023
PubMed
概括

研究人员开发了针对蛋白质降解的新型内细胞酶触发结合蛋白 (EndoTags). 这些可遗传编码的EndoTags克服了现有方法的局限性,并为各种应用提供了治疗潜力.

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