芯片上的大脑器官可以在前脑器官中创建多个域
bioRxiv : the preprint server for biology
|October 2, 2023
概括
大脑器官在芯片上的平台创建信号梯度,以开发拓前脑器官. 这种先进的模型提供了对人类神经发育和疾病的更详细的评估.
科学领域:
- 神经科学是一个神经科学.
- 干细胞生物学 干细胞生物学
- 生物技术是生物技术.
背景情况:
- 来自多能干细胞的脑器官是研究大脑发育和疾病的有价值的体外模型.
- 当前的3D大脑器官模型很难复制生理条件,比如信号梯度.
研究的目的:
- 开发一个新的脑器官芯片平台.
- 为了在3D大脑器官中产生受控的信号梯度.
- 诱导拓前脑器官,模仿大脑区域的连续光谱.
主要方法:
- 利用微流体技术创建了脑器官芯片系统.
- 在体外生成稳定的信号梯度的既定方法.
- 培养的多能干细胞形成拓前脑器官.
主要成果:
- 在有机体系统中成功生成可重现的信号梯度.
- 诱导了地形前脑有机体的形成,具有明显的区域化.
- 与传统的有机体相比,大脑区域的频谱更为连续.
结论:
- 大脑器官芯片平台代表了大脑器官技术的重大进步.
- 这些平台为评估神经发育和疾病建模提供了前所未有的细节.
- 这种方法有助于在体外更深入地了解人类大脑.
相关概念视频
Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
Cerebrum: Anatomical Overview I
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
Cerebrum: Anatomical Overview II
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Cerebellum: Anatomical Regions
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...


