相关实验视频
Updated: Jul 15, 2025
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.6K
新发病的慢性自发性疹在COVID-19疫苗接种后 - 南非病例系列
Valmy Craffert1, Cascia Day1,2, Jonny Peter1,2
1Allergy and Immunology Unit, University of Cape Town Lung Institute, Mowbray, Cape Town, South Africa.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
接种COVID-19疫苗很少会引发新发的慢性自发性疹 (CSU). 这个南非病例系列发现CSU症状在几周内出现,通常是在mRNA疫苗后出现的,并且与其他CSU触发因素类似.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 慢性自发性疹 (CSU) 具有持续超过六周的疹和/或血管的特征.
- 虽然一般耐受性很好,但COVID-19疫苗与CSU发病有事相关.
- 这项研究详细介绍了COVID-19疫苗接种引发的CSU的第一个非洲病例系列.
研究的目的:
- 在南非接种COVID-19疫苗后,报告新出现的CSU.
- 总结关于疫苗引发的CSU病例的全球文献.
主要方法:
- 在开普敦疹卓越中心对患者的回顾性审查.
- 纳入标准:在COVID-19疫苗接种12周内新出现的CSU (2021年2月至2022年8月).
- 分析病史,体检和实验室数据.
主要成果:
- 8名患者进行了新发病的CSUCOVID-19后疫苗接种.
- 大多数是女性 (6/8),平均年龄为41岁,有过亚托皮病史.
- CSU的发病发生在接种疫苗后12天的中位数,最常见的是mRNA疫苗 (Pfizer-BioNTech) 后.
- 在63%的患者中发现IgE水平升高;抗组胺治疗往往不足.
结论:
- 接种COVID-19疫苗是新发性CSU的罕见触发因素.
- 疫苗引发的CSU的表现与其他因素引起的类似.
- 在本系列中,mRNA疫苗最常与CSU发展有关.
相关概念视频
02:06Allergic Reactions
27.7K
Overview
27.7K
01:27Allergic Drug Reactions
873
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
873
01:30Hypersensitivities
718
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
718
00:42Cross-reactivity
31.2K
Overview
31.2K
01:51Vaccinations
44.6K
Overview
44.6K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
326
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
326