短链脂肪酸通过顺序诱导PMN-MDSCs和Treg细胞来改善过敏气道炎症
Min-Ting Huang1, Chiao-Juno Chiu2, Ching-Yi Tsai1
1Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
The journal of allergy and clinical immunology. Global
|October 2, 2023
概括
短链脂肪酸 (SCFA) 通过顺序诱导髓质衍生抑制细胞 (MDSC) 和调节性T (Treg) 细胞来减少过敏性喘. 这种免疫调节途径涉及PMN-MDSCs和TGF-β,为喘提供了一种新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 微生物组与宿主之间的相互作用
背景情况:
- 通过加强免疫调节通路,可以控制过敏性喘.
- 众所周知,微生物发酵产物短链脂肪酸 (SCFA) 诱导调节性T (Treg) 细胞,并具有免疫调节作用.
- 在喘中SCFA介导的免疫调节的精确细胞机制仍然不完全理解.
研究的目的:
- 调查骨髓衍生抑制细胞 (MDSC) 和Treg细胞在SCFA介导的防治过敏气道炎症中的作用.
- 阐明SCFA在喘小鼠模型中发挥保护作用的细胞机制.
主要方法:
- 在诱导卵胺诱导喘之前,BALB/c小鼠被给予SCFA.
- 用GR1消耗抗体来消耗骨髓原抑制细胞 (MDSC),以评估它们在过敏呼吸道炎症中的功能.
- 分离并分析了MDSCs的免疫抑制能力和与T细胞的相互作用.
主要成果:
- 施用SCFA导致喘严重程度降低,与PMN-MDSCs和Treg细胞增加相关.
- 在PMN-MDSCs的耗尽加剧了喘,废除了SCFA的保护作用.
- SCFA直接促进了Treg细胞分化,PMN-MDSC通过细胞接触增强了Treg扩张,部分由TGF-β调解.
结论:
- 通过顺序诱导PMN-MDSCs和Treg细胞,SCFA可以改善过敏气道炎症.
- 这项研究确定了一种新的免疫调节级联,涉及MDSC和Treg细胞在SCFA介导的喘保护中.
- 这些发现表明,通过准SCFA-MDSC-Treg轴来治疗过敏性喘,这是一个有希望的治疗途径.
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