通过饮食预防阿尔茨海默病:一个探索性审查
Nusrat Zahan Bhuiyan1, Md Kamrul Hasan1,2, Zimam Mahmud3
1Department of Biochemistry and Molecular Biology, National University Bangladesh, Gazipur, 1704, Bangladesh.
Metabolism open
|October 2, 2023
概括
坚持像地中海饮食这样的饮食可以显著降低阿尔茨海默病的风险. 然而,这些营养丰富的食物的高成本对广泛预防阿尔茨海默病提出了挑战.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 遗传学 是一个遗传学.
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,具有复杂的遗传基础.
- 人们越来越认识到饮食模式和社会经济因素对阿兹海默症风险和预防的潜在影响.
- 了解遗传倾向,饮食和认知健康之间的相互作用对于开发有效的AD管理策略至关重要.
研究的目的:
- 探索与阿尔茨海默病 (AD) 相关的遗传因素.
- 调查饮食模式,食物成分和AD风险之间的关系.
- 通过营养研究影响AD预防的社会经济挑战.
主要方法:
- 在Scopus,PubMed和谷歌学者中进行了全面的文献搜索.
- 关键词包括阿尔茨海默病,遗传因素 (APoE4,陶蛋白,APP,β-粉样蛋白),饮食模式 (地中海饮食,DASH饮食,MIND饮食) 和社会经济状况.
- 使用VOSviewer进行网络分析,以可视化搜索术语之间的关系.
主要成果:
- 坚持地中海饮食 (MD) 和MIND饮食与AD风险显著降低 (高达53%) 有关.
- 像Omega-6 PUFA和维生素D这样的特定营养素显示出清除β-粉样蛋白 (Aβ) 和抑制亡的潜力.
- 营养丰富食品的高成本对实施AD预防饮食干预措施构成重大障碍.
结论:
- 饮食在调节阿尔茨海默病生物标志物和风险方面发挥着重要作用.
- 需要进一步的研究,以确定营养作为AD的最终风险或保护因素.
- 将营养发现转化为可访问的治疗实践,需要解决食品获取方面的经济差异.
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