用于口腔粘膜输送的微针 - 目前的趋势和未来方向的前景
Luiz E N Ferreira1, Michelle Franz-Montan2, Bruna Benso3,4
1Laboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, SP, Brazil.
Expert opinion on drug delivery
|October 2, 2023
概括
微针 (MNs) 为口腔药物和疫苗的输送提供了一个有希望的方法,克服了当前方法的局限性. 这项技术几乎没有疼痛,并且在各种口腔粘膜应用中有效.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 口服粘膜治疗药物 口服粘膜治疗药物
背景情况:
- 口腔药物和疫苗的输送目标是局部向和减少系统性副作用.
- 目前的输送方法在有效到达口腔粘膜方面存在局限性.
- 微针 (MNs) 为增强口腔粘膜输送提供了一种新的解决方案.
研究的目的:
- 对口腔中微针 (MN) 应用的文献进行审查.
- 评估MNs在口腔粘膜中用于药物和疫苗的潜力.
- 评估MNs在各种口服应用中的安全性和有效性.
主要方法:
- 文献综述包括体外研究,体内动物研究和人类临床试验.
- 对MN属性的分析,包括口服时的强度和疼痛感知.
- 检查MNs在疫苗接种,局部麻醉剂的使用和口腔病理的治疗中的实用性.
主要成果:
- 微针 (MNs) 足够坚固,可以穿透口腔表皮.
- 在各种口腔粘膜部位 (唇,脸,舌头, palates) 上,MN的应用几乎是无痛的.
- 在疫苗接种,麻醉和治疗口腔病变/癌症方面,MN已经显示出潜力.
结论:
- 微针 (MNs) 是口服药物和疫苗的有希望的技术.
- 多种类型的药物提供了改善治疗结果的潜力,在口腔中减少了副作用.
- 预计未来将在牙科和口腔医学中对MN发展进行重大研究.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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01:16Drug Delivery: Overview
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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01:18Drug Delivery: Enteral Route
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
489
01:15Non-Oral Extravascular Drug Absorption Routes
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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
231