在患有精神疾病的患者中肝转氨酶的升高
Eman Ali1, Mona Ahmed Abdel Maksoud2, Shaymaa M Arafa3
1Psychiatry Department, Faculty of Medicine, Zagazig University.
International clinical psychopharmacology
|October 2, 2023
概括
抗精神病药物 (AD) 对于精神病患者来说通常是安全的,肝酶升高 (透视炎) 的发生率很低. 在AD治疗期间,建议定期监测肝功能.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝细胞损伤通常使用血清阿斯巴酸氨酸酶和氨酸氨酸酶水平进行评估.
- 抗精神病药物 (AD) 经常与精神病患者群体中的肝功能障碍有关.
- 在接受AD治疗的精神病患者中评估跨氨炎的发病率对于患者的安全至关重要.
研究的目的:
- 为了评估成年精神病患者治疗抗精神病药物 (AD) 的跨氨炎的发生情况.
主要方法:
- 在埃及的扎加齐格大学医院,从2022年12月到2023年2月进行了一项横截面研究.
- 包括135名患有精神疾病的成年患者,不包括具有混因素的患者.
- 在接受AD的患者中监测血清中氨酸酶水平,重点关注非典型的AD和联合AD疗法.
主要成果:
- 在接受AD的患者中,透氨炎的总发病率为17.04% (23/135).
- 在那些患有透氨炎的人中,56.5%患有非典型的AD,43.5%患有联合AD,没有统计学上显著的差异.
- 大多数透氨炎病例 (<1倍升高) 表示肝酶升高最小.
结论:
- 在精神病患者中使用抗精神病药物 (AD) 似乎总体上是安全的,与较低的微小透视膜炎率有关.
- 建议在AD治疗期间对精神病患者进行血清氨基转移酶水平的基线和定期监测,以确保肝脏健康.
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