相关实验视频

Updated: Jul 15, 2025

Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System
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复制诱导的DNA二次结构驱动了分叉解和断裂

Sophie L Williams1, Corella S Casas-Delucchi1, Federica Raguseo2,3

  • 1Genome Replication Lab, Division of Cancer Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

The EMBO journal
|October 2, 2023
PubMed
概括

像G-四复合体 (G4s) 和介质动机 (iMs) 这样的DNA二次结构可以阻止DNA复制. 皮夫1酶能够解决这些结构,防止基因组的不稳定性和复制压力.

关键词:
复制DNA复制DNA复制DNA复制DNA的二次结构是DNA的二次结构.在G-quadruplex和i-Motif中使用.基因组稳定性的基因组稳定性复制压力是复制的压力.

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