在长期瘤抑制的微波热疗法后,H2S-再激活抗瘤免疫反应
Shimei Li1,2,3, Fanyi Xu1,2, Xiangling Ren1,2
1Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
ACS nano
|October 2, 2023
概括
这项研究引入了一种新的纳米免疫调节器,通过释放硫化 (H2S) 来增强微波热疗法 (MWTT). 这种方法可以逆转瘤诱导的免疫抑制,重新激活抗瘤免疫力,并减少除后癌症复发.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 免疫治疗是一种免疫疗法.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 微波热疗法 (MWTT) 是一种有效的除性癌症治疗方法,但缺乏瘤选择性.
- 不完整的切除可以导致残留的瘤,导致免疫抑制,增加癌症复发和转移风险.
- 目前的MWTT策略需要加强以克服瘤诱导的免疫抑制.
研究的目的:
- 开发一种纳米免疫调节器 (BMCPH),以提高MWTT的疗效.
- 为了利用响应性的硫化 (H2S) 释放来逆转免疫抑制并增强抗瘤免疫力.
- 降低MWTT后瘤复发和转移的风险.
主要方法:
- 一种新型的纳米免疫调节剂Bi-MOF-l-Cys@PEG@HA (BMCPH) 被合成.
- 在微波辐射下,BMCPH释放l-氨酸 (l-Cys),在瘤细胞中产生H2S.
- 这项研究研究了H2S在抑制髓质衍生抑制细胞 (MDSC) 和促进细胞毒性T淋巴细胞 (CTL) 的作用,以及Bi-MOF的ROS清理能力.
主要成果:
- 生成的H2S抑制了MDSC积累并促进了CTL表达,从而逆转了免疫抑制.
- 双MOF成分有效地清除了活性氧物种 (ROS),进一步削弱了免疫抑制.
- 在BMCPH上的HA涂层促进了瘤周围的CTL聚合,增强了免疫反应.
结论:
- 开发的纳米气体免疫调节器 (BMCPH) 为瘤部位可调节的H2S释放提供了一种策略.
- 释放H2S有效地逆转免疫抑制,并重新激活抗瘤免疫反应.
- 这种方法在减少热切切除后的瘤复发和转移方面表现有希望.
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