2023年ASCO生殖尿道癌症研讨会:聚焦泌尿器癌
Antonio Cigliola1, Viria Beccia1, Annunziato Anghelone1
1Medical Oncology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.
Expert review of anticancer therapy
|October 2, 2023
概括
辅助尼沃卢马布改善了肌肉侵入性尿路细胞癌的存活率. 新数据显示,免疫疗法组合在转移性尿路细胞癌中是无效的,但试验性疗法显示出有前途.
科学领域:
- 尿瘤学 尿瘤学
- 医学瘤学 医学瘤学
- 生殖尿道癌症 生殖尿道癌症
背景情况:
- 尿路癌 (UC) 管理在2023年美国临床瘤学会生殖尿路癌症研讨会上提出的新数据发展.
- 关键更新侧重于辅助和转移性环境,以及新的治疗策略.
研究的目的:
- 总结来自2023年ASCO生殖尿道癌症研讨会的泌尿腺癌治疗方面的重大进展.
- 突出辅助疗法的新发现,一线转移性治疗,以及耐火性疾病的新兴选择.
主要方法:
- 从2023年ASCO生殖尿道癌症研讨会的关键演讲和数据的审查.
- 分析临床试验结果关于免疫疗法,化疗和抗体-药物合物在尿路细胞癌.
主要成果:
- 辅助药尼沃卢马布在高风险的肌肉侵入性UC中表现出无病生存优势,随访时间更长.
- 第一线免疫疗法组合 (阿特佐利祖马布+化疗) 和阿特佐利祖马布单一疗法未能改善转移性UC (mUC) 的整体存活率.
- 布罗利祖马布在高风险的非肌肉侵入性膀癌中表现有前途,这种癌症不耐卡尔梅特 - 格林菌;沙基图祖马布戈维特康在不合格的mUC中表现出活性.
结论:
- 辅助剂尼沃卢马布是针对特定高风险的肌肉侵入性UC的一种已确认的选择.
- 目前在转移性UC的第一线免疫治疗策略需要重新评估.
- 新兴的药物,如 pembrolizumab 和 sacituzumab govite,可以为耐火性UC提供新的希望.
- 对于个性化的UC治疗,预测生物标志物的需求至关重要.
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