在患有1型糖尿病和HbA1c升高的儿童中12周自由运动2.0的效果:多中心随机对照试验
Craig A Jefferies1,2, Alisa Boucsein3, Sara E Styles4
1Starship Child Health, Te Whatu Ora-Health New Zealand, Te Toka Tumai Auckland, Auckland, New Zealand.
Diabetes technology & therapeutics
|October 2, 2023
概括
间歇扫描连续血糖监测 (isCGM) 改善了1型糖尿病儿童的血糖检测频率,减少了低于范围的时间. 然而,与自我监测血糖 (SMBG) 相比,isCGM并没有显著降低HbA1c或改善心理社会结果.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 糖尿病 技术 技术
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 儿童1型糖尿病 (T1D) 的管理需要有效的血糖控制.
- 血糖血红蛋白 (HbA1c) 升高表明葡萄糖管理不足.
- 间歇扫描连续血糖监测 (isCGM) 为传统的自我监测毛细血管血糖 (SMBG) 提供了替代方案.
研究的目的:
- 为了比较isCGM与SMBG在降低T1D儿童的HbA1c和高血糖控制的疗效.
- 评估isCGM对葡萄糖监测频率和在各种葡萄糖范围内的时间的影响.
- 评估isCGM对儿科T1D患者心理社会结果的影响.
主要方法:
- 一项为期12周的多中心随机对照试验,涉及100名儿童 (4至13岁) 患有T1D和HbA1c在7.5%至12.2%之间.
- 参与者被随机分配到isCGM (FreeStyle Libre 2.0) 或SMBG.
- 主要结局:从基线到12周HbA1c的变化. 二级结局包括血糖监测频率,范围以下时间 (TBR) 和心理社会分数.
主要成果:
- 在isCGM和SMBG组之间的HbA1c变化没有显著差异 (0.23%的差异,P=0.3).
- isCGM显著增加了血糖监测频率 (+4.89读数/天,P<0.001),并减少了低于范围的时间 (-6.4%,P<0.001).
- 两组之间的父母或儿童心理社会结果得分没有显著差异.
结论:
- 在患有T1D和HbA1c升高的儿童中,isCGM在12周内改善了血糖监测频率和降低了低血糖 (低于范围的时间).
- 与SMBG相比,isCGM没有导致HbA1c的统计显著降低或心理社会结果的改善.
- 可能需要进一步的研究来探索isCGM在儿科T1D管理中的长期影响和最佳整合.
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