格兰辛林囊通过抑制炎症和恢复内皮功能来改善冠状动脉微血管功能障碍
M-Y Dong1, H-Y Jiang, Y-Y Wang
1Department of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, China. guapa66832814@163.com.
European review for medical and pharmacological sciences
|October 2, 2023
概括
格兰西宁囊 (GXSC) 通过减少炎症和改善内皮功能,有效地治疗冠状动脉疾病 (CAD) 患者的冠状动脉微血管功能障碍 (CMD). 这种中医药对心肌痛患者有着非阻塞性心上冠状动脉的有前途.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 冠状动脉疾病 (CAD) 可能涉及冠状动脉微血管功能障碍 (CMD),这种疾病的治疗尚未完全理解.
- 凝素囊 (GXSC) 是一种由Pueraria lobata,棘提取物和gypenosides组成的传统中医药,用于CAD,但其对CMD的影响尚不清楚.
研究的目的:
- 研究GXSC在改善CAD患者的CMD中的治疗效果.
- 阐明GXSC对CMD炎症和内皮功能作用的潜在机制.
主要方法:
- 一个单中心,随机对照试验,涉及78名通过冠状动脉血管学 (CAG) 诊断的CAD患者.
- 通过CAG和SPECT进行的测量包括微循环阻力指数 (IMR) 和冠状动脉流量储量 (CFR).
- 在治疗前两个月和治疗后使用ELISA量化炎症,内皮功能和微血管功能的生物标志物.
主要成果:
- GXSC治疗显著降低了促炎性标志物 (NLRP3,IL-1) 和增加了抗炎性阿德罗.
- 内皮功能标记物 (合成 1,合成 4,肝素硫酸盐) 被下调,而血管保护性SIRT1被GXSC上调.
- 冠状动脉微血管功能标志物 (内分泌,suPAR,GDF-15) 在GXSC组显著降低.
结论:
- 在CAD患者中,GXSC通过抑制炎症和恢复内皮功能来证明对CMD的治疗效果.
- GXSC可以作为CAD患者的有效治疗选择,因为CMD患有心肌痛,特别是那些没有阻塞性心上冠状动脉的患者.
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