系统性炎症反应指数与NSTEMI患者的MACE相关
M O Ozilhan1, O Çakmak Karaaslan, S K Acikgoz
1Department of Cardiology, Ankara City Hospital, Ankara, Turkey. moozilhan@gmail.com.
European review for medical and pharmacological sciences
|October 2, 2023
概括
系统性炎症反应指数 (SIRI) 预测了非ST升高心肌梗塞 (NSTEMI) 患者的主要不良心血管事件 (MACE). 较高的SIRI水平表明风险增加,有助于预后评估.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 非ST段升高心肌梗塞 (NSTEMI) 是一个重要的心血管问题.
- 系统性炎症反应指数 (SIRI) 是一种新兴的炎症标志物,在心血管疾病中具有潜在的相关性.
- 关于SIRI和NSTEMI结果之间的特定关联尚未得到充分证实.
研究的目的:
- 在NSTEMI患者中调查SIRI和主要心血管不良事件 (MACE) 之间的相关性.
- 确定SIRI是否可以在这个人群中作为MACE的独立预测因子.
- 探索SIRI在NSTEMI管理中的预后价值.
主要方法:
- 分析了一组935名接受皮肤间干预的NSTEMI患者.
- MACE被定义为全因死亡,恶性心律失常,或无计划的皮肤冠状动脉干预.
- 计算SIRI为 (中性粒细胞数 *单细胞数) /淋巴细胞数;ROC曲线分析确定了MACE预测切线.
主要成果:
- 发现SIRI是NSTEMI患者中MACE的独立预测因子.
- 一个SIRI切线为2.3显示了68%的敏感性和76%的特异性MACE检测.
- 在MACE.患者和没有MACE.患者之间,平均SIRI水平显著不同.
结论:
- 在NSTEMI的背景下,SIRI是MACE的强有力的独立预测器.
- 在NSTEMI患者中,SIRI具有作为不良心血管事件的预后指标的潜力.
- 这些发现有助于理解NSTEMI病理生理学,并可能指导临床管理.
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