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Updated: Jun 14, 2026

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使用聚焦DNA编码图书馆屏幕发现了一个53BP1小分子对手

Devan J Shell1, Caroline A Foley1, Qinhong Wang2

  • 1UNC Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Journal of medicinal chemistry
|October 2, 2023
PubMed
概括

研究人员开发了UNC9512,是一种强大的小分子对抗剂,向p53结合蛋白1 (53BP1). 这种化学探测器有助于研究53BP1BP1.

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相关概念视频

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...