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长非编码RNA作为细胞应激反应和恒温的多功能分子调节器

Julia Scholda¹, Thi Thuy Anh Nguyen¹, Florian Kopp²

¹Faculty of Life Sciences, Department of Pharmaceutical Sciences, Clinical Pharmacy Group, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.

|October 2, 2023

概括

哺乳动物细胞使用应激反应通路来维持平衡. 本综述对参与这些途径的长非编码RNA (lncRNA) 进行了分类,澄清了它们在压力和正常生理学中的作用.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

细胞平衡至关重要,并受到进化的应激反应通路的保护.
哺乳动物细胞采用多种途径来管理压力刺激,预防疾病.
非蛋白质编码RNAs,包括长非编码RNAs (lncRNAs),越来越多地认识到它们在应激反应中的作用.

研究的目的:

为分类涉及应激反应和恒温的哺乳动物 lncRNAs提供一个框架.
阐明特定与压力相关的 lncRNAs 的分子功能和生理作用.
概念化 lncRNAs 如何作为哺乳动物应激反应中的多功能调节剂.

主要方法:

文献综述和对应激反应中的lncRNAs现有研究的综合.
基于实验验证的作用模式对 lncRNAs 的分类.
分析所选 lncRNAs 的分子功能和生理作用.

主要成果:

提出了一个框架来对哺乳动物 lncRNAs 在应激反应中进行分类.
描述了lncRNAs及其在细胞压力中的功能的具体例子.
lncRNAs被确定为在压力期间维持平衡的多功能贡献者.

结论:

lncRNAs在哺乳动物的压力反应中起着关键的,但往往不太了解的作用.
提出的分类和概念可以指导新 lncRNA 和功能的发现.
了解 lncRNA 在压力中的作用对于了解正常生理学和疾病至关重要.

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